SPONTANEOUS ACTIVITY OF NEONATALLY ESTROGENIZED FEMALE RATS

Spontaneous activity of neonatally estrogenized female rats.

Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats.

Neonatal exposure to estrogens permanently alters rat prostate growth and epithelial differentiation leading to prostatic dysplasia on aging. The effects are lobe-specific, with the greatest response observed in the ventral lobe. Recently, a novel estrogen receptor (ER) complementary DNA was cloned from the rat prostate and termed ER-beta (ER beta) due to its high homology with the classical ER...

Experimental Studies on Morphological Changes of the Epididymis and Testis in Neonatally Estrogenized Mice Revisited

Our primary concern in this review is to give possible explanations and pose new questions on the phenomena concerning eff ects of neonatal estrogen exposure on the development and functions of reproductive organs and immune mechanisms particularly in male animals, in the light of new fi ndings and cencepts. At fi rst, our own experimental results on the pathological changes in the epididymis a...

Neonatally induced mild diabetes: influence on development, behavior and reproductive function of female Wistar rats

BACKGROUND Neonatal STZ treatment induces a state of mild hyperglycemia in adult rats that disrupts metabolism and maternal/fetal interactions. The aim of this study was investigate the effect of neonatal STZ treatment on the physical development, behavior, and reproductive function of female Wistar rats from infancy to adulthood. METHODS At birth, litters were assigned either to a Control (s...

Persistent Spontaneous Oral Dyskinesias in Haloperidol- Withdrawn Rats Neonatally Lesioned with 6-Hydroxydopamine:

To investigate the influence of dopamine (DA) nerves on haloperidol (HAL)-induced oral dyskinesias, rats were first injected at 3 days after birth with 6-hydroxydopamine HBr (200 mg i.c.v., salt form; 6-OHDA) or vehicle, after desipramine HCl (20 mg/kg i.p., 1 hr) pretreatment. Two months later HAL (1.5 mg/kg/day, 2 days a week for 4 weeks, then daily for 10 months) was added to the drinking wa...